ODCs

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5 OMIM references -
4 associated genes
11 signs/symptoms

PROTEIN INTERACTIONS: 2
COMMON SIGNS: 2

Li-Fraumeni syndrome

3 OMIM references -
2 associated genes
16 signs/symptoms

Nephroblastoma

Li-Fraumeni syndrome

DIS3L2	(UniProt - OMIM)		CHEK2	(UniProt - OMIM)
H19	(OMIM)		TP53	(UniProt - OMIM)
POU6F2	(UniProt - OMIM)
WT1	(UniProt - OMIM)


INTERACTOME ASSOCIATIONS (click on a score value to see the evidence)	WT1 H19	(0.86) (0.63)	TP53 TP53

Citations in the biomedical literature:

Nephroblastoma		Li-Fraumeni syndrome
	Synonym(s): - Renal embryonic tumor - Wilms tumor		Synonym(s): (no synonyms)

	Classification (Orphanet): - Rare genetic disease		Classification (Orphanet): - Rare endocrine disease - Rare genetic disease - Rare neurologic disease - Rare oncologic disease

	Classification (ICD10): - Neoplasms -		Classification (ICD10): - Neoplasms -

	Epidemiological data: Class of prevalence: 1-9 / 100 000 Average age onset: childhood Average age of death: any age Type of inheritance: autosomal dominant		Epidemiological data: Class of prevalence: unknown Average age onset: adulthood Average age of death: - Type of inheritance: autosomal dominant

	External references: 5 OMIM references - 1 MeSH reference: D009396		External references: 3 OMIM references - 1 MeSH reference: D016864


COMMON SIGNS	- Lung / bronchopulmonary neoplasm / tumor / carcinoma / cancer - Neoplasms / tumors

Nephroblastoma		Li-Fraumeni syndrome
	Very frequent - Acute abdominal pain / colic - Kidney / renal neoplasm / tumor / carcinoma / cancer Occasional - Aniridia / iris hypoplasia - Chronic arterial hypertension - Fever / chilling - Hematuria / microhematuria - Hepatic / liver neoplasm / tumor / carcinoma / cancer - Lymphadenopathy / polyadenopathies - Weight loss / loss of appetite / break in weight curve / general health alteration		Very frequent - Acute leukemia - Autosomal dominant inheritance - Bone / osseous neoplasm / tumor / carcinoma / cancer - Breast neoplasm / tumor / carcinoma / cancer - Central nervous system / peripheral nerves neoplasm / tumor / carcinoma / cancer - Colon neoplasm / tumor / carcinoma / cancer - Cortical adrenal neoplasm / tumor / carcinoma / cancer - Lymphoma - Pancreatic / pancreas neoplasm / tumor / carcinoma / cancer - Sarcoma - Skin / cutaneous neoplasm / tumor / carcinoma / cancer (excluding melanoma) - Soft tissue sarcoma / cancer / tumor / liposarcoma / myosarcoma Occasional - Melanoma - Oropharyngeal neoplasm / tumor / carcinoma / cancer